Upstream scientist

SENIOR BIOPROCESS UPSTREAM DEVELOPMENT SCIENTIST

Location: Dublin
Department: Technical Operations
Reports to: Biologics Functional Lead

ABOUT THE ROLE

We are seeking a Senior Bioprocess Upstream Development Scientist to support the development, optimisation, characterisation, scale-up and technology transfer of upstream biopharmaceutical processes.

The role involves hands-on laboratory work with small- and pilot-scale bioreactors, including AMBR systems. The primary focus is mammalian cell culture, although experience in microbial fermentation, viral vectors, vaccines, or cell and gene therapies is also relevant.

KEY RESPONSIBILITIES

• Plan and execute upstream process-development studies.
• Develop and optimise mammalian, adherent or microbial cell-culture processes.
• Operate laboratory and pilot-scale bioreactors.
• Develop scale-up strategies and representative scale-down models.
• Design experiments covering media, feeds and process parameters.
• Apply DOE, QbD and statistical approaches where appropriate.
• Analyse data and troubleshoot process or equipment issues.
• Support technology transfer into pilot or manufacturing environments.
• Prepare technical reports and present findings to stakeholders.
• Collaborate with internal teams, clients and external partners.
• Mentor less experienced scientists where required.

REQUIREMENTS

• Degree, MSc or PhD in biotechnology, biochemical engineering, bioprocessing or a related discipline.
• Relevant upstream biopharmaceutical process-development experience.
• Hands-on experience with laboratory or pilot-scale bioreactors.
• Experience in mammalian, adherent or microbial cell culture.
• Strong experimental design, data analysis, technical writing and presentation skills.
• Ability to work effectively in a multidisciplinary and client-facing environment.

DESIRABLE EXPERIENCE

• AMBR 250, AMBR 15 or similar automated bioreactor systems.
• CHO, HEK or comparable production cell lines.
• Fed-batch or perfusion process development.
• Process scale-up, scale-down and technology transfer.
• DOE, QbD, JMP or related statistical tools.
• Biologics, viral-vector, vaccine or cell and gene therapy development.

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